is renal, with approximately 80 of the administered dose appearing in the urine as unchanged medicinal product. In these cases the dose may have to be doubled. Vitamin A : Based on a case-report in one patient receiving combination therapy with all-trans-retinoid acid (an acid form of vitamin A) and fluconazole, CNS related undesirable effects have developed in the form of pseudotumour cerebri, which disappeared after discontinuation of fluconazole treatment. (See sections.2 Posology and method of administration and.4 Special warnings and special precautions for use). Drugs affecting the metabolism of itraconazole Itraconazole is mainly metabolised through the cytochrome CYP3A4. These breakpoints are given in the table below: Antifungal Species-related breakpoints (S/R ) Non-species related breakpointsA S/R Candida albicans Candida glabrata Candida krusei Candida parapsilosis Candida tropicalis Fluconazole 2/4 IE - 2/4 2/4 2/4 S Susceptible, R Resistant A Non-species related breakpoints have been determined. Potent inhibitors of this enzyme such as ritonavir, indinavir, clarithromycin and erythromycin may increase the bioavailability of itraconazole. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested.
The plastic box is handy and sturdy, and appropriate to be carried n a bag or a purse. The mirror is also good. And I especially like the applicator it has a broad end and a narrow end for normal and fine applications respectively. Each capsule contains fluconazole 50mg.
Patients should be instructed to promptly report to their physician signs and symptoms suggestive of hepatitis such as anorexia, nausea, vomiting, fatigue, abdominal pain or dark urine. Effective contraception should be continued until the menstrual period following the end of itraconazole therapy. In cases of fluconazole associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex code promo delamaison novembre or age of patient has been observed. Pregnancy An observational study has suggested an increased risk of spontaneous abortion in women treated with fluconazole during the first trimester. 4.8 Undesirable effects Undesirable effects listed below have been reported in clinical trials with itraconazole capsules and/or from spontaneous reports from post-marketing experience for all itraconazole formulations.